Clinical Trial: Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.

Brief Summary:

Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate.

Minor data is available regarding the influence on male sperm.

Detailed Summary: Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.
Sponsor: Hillel Yaffe Medical Center

Current Primary Outcome: pregnancy [ Time Frame: 24 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome: ROS (reactive oxidative stress )and Interleukins level in semen fluid [ Time Frame: 12 weeks ]

Original Secondary Outcome: Same as current

Information By: Hillel Yaffe Medical Center

Dates:
Date Received: July 14, 2013
Date Started: September 2013
Date Completion: September 2014
Last Updated: August 6, 2013
Last Verified: July 2013