Clinical Trial: Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Transcranial Magnetic Stimulation Treatment of Hoarding Disorder
Brief Summary: This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.
Detailed Summary: Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.
Sponsor: Hartford Hospital
Current Primary Outcome: The Saving Inventory-Revised (SI-R) Total Score [ Time Frame: Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up ]
Original Primary Outcome: change in discarding subscale of The Saving Inventory-Revised (SI-R) [ Time Frame: Participants will be assessed weekly for the duration of the study (average duration will be 10 weeks) ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Hartford Hospital
Dates:
Date Received: September 4, 2014
Date Started: July 2014
Date Completion:
Last Updated: August 15, 2016
Last Verified: August 2016