Clinical Trial: Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery
Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title:
Brief Summary: Regional anesthesia may decrease the release of endogenous opioids, increase Natural Killer cell (NK) function and decrease development of metastasis. The recent analysis of the Cancer Registry has noted an improved 5-year survival in patients who received epidural analgesia during surgery for colorectal carcinoma.
Detailed Summary:
Sponsor: Hillel Yaffe Medical Center
Current Primary Outcome:
- Count of live and dead target erythroleukemic cells [ Time Frame: 72 hours ]All clinical and laboratory parameters from blood samples taken before and after the operation will be compared between the two groups of patients. The nominal data comparison will be performed by ANOVA test, and the nonparametric data will be performed by Mann-Whitney test and interquartile ranges (IQR) for non-normally distributed data.
- Plasma concentration of cytokines [ Time Frame: 72 hours ]All clinical and laboratory parameters from blood samples taken before and after the operation will be compared between the two groups of patients. The nominal data comparison will be performed by ANOVA test, and the nonparametric data will be performed by Mann-Whitney test and interquartile ranges (IQR) for non-normally distributed data.
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Hillel Yaffe Medical Center
Dates:
Date Received: December 10, 2014
Date Started: April 2015
Date Completion: May 2017
Last Updated: December 22, 2014
Last Verified: December 2014
