Clinical Trial: Single Dose Versus Multiple Doses of Dexamethasone in Children With Acute Bronchiolitis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Efficacy of Single Dose Versus Multiple Doses of Dexamethasone in Outpatients With Acute Bronchiolitis

Brief Summary: This study is to determine the effectiveness of five-day treatment versus a single dose of oral dexamethasone (corticosteroid) in children between 2 and 24 months of age with a first episode of acute bronchiolitis presenting in the Emergency Department

Detailed Summary:
Sponsor: The Hospital for Sick Children

Current Primary Outcome: Proportion of patients stabilized, discharged and subsequently hospitalized and/or co-interventions with corticosteroids or beta2 agonists outside the protocol within the 6 day study period

Original Primary Outcome: - Proportion of patients stabilized, discharged and subsequently hospitalized and/or co-interventions with corticosteroids or beta2 agonists outside the protocol within the 6 day study period

Current Secondary Outcome:

  • Respiratory Assessment Change Score (RACS) at 96 and 144 hours
  • Proportion of infants with unscheduled medical visits for respiratory distress within the 6 day study period
  • Proportion of infants with no signs of respiratory distress at 96 and 144 hours
  • Proportion of infants who are symptomatic at 14 days


Original Secondary Outcome:

  • - Respiratory Assessment Change Score (RACS) at 96 and 144 hours
  • - Proportion of infants with unscheduled medical visits for respiratory distress within the 6 day study period
  • - Proportion of infants with no signs of respiratory distress at 96 and 144 hours
  • - Proportion of infants who are symptomatic at 14 days


Information By: The Hospital for Sick Children

Dates:
Date Received: September 13, 2005
Date Started: December 2001
Date Completion:
Last Updated: May 12, 2014
Last Verified: May 2014