Clinical Trial: Randomized Study of Intensive One-on-one Behavioral Treatment for Preschool Aged Children With Autism

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Randomized Study of Intensive One-on-one Behavioral Treatment Versus Individualized Parent Training in Preschool Aged Children With Autism

Brief Summary:

OBJECTIVES: I. Determine the effectiveness of intensive one-on-one behavioral treatment in the home or neighborhood compared with at home, individualized, parent training in preschool aged children with autism.

II. Identify intake measures that predict differences in outcome between subjects in the experimental group.


Detailed Summary:

PROTOCOL OUTLINE: This is a randomized study. Children are randomized to receive either 35 hours of intensive one-on-one behavioral treatment in the home and neighborhood for 2 years or individualized, in home parent training for 6 months.

A common group of tests to evaluate autism are administered at intake, 12 and 24 months into treatment, and when patients reach age 6.


Sponsor: University of California, Los Angeles

Current Primary Outcome:

  • Wechsler Preschool and Primary Scales of Intelligence, 3rd ed. [ Time Frame: yearly for up to 4 years ]
    IQ
  • Bayley Scales of Infant Development [ Time Frame: yearly for up to 4 years ]
    Alternate cognitive test administered to participants who did not achieve basal on WPPSI-III


Original Primary Outcome:

Current Secondary Outcome:

  • Merrill-Palmer Scale of Mental Tests [ Time Frame: yearly for up to 4 years ]
    Nonverbal cognitive skills
  • Reynell Developmental Language Scales [ Time Frame: yearly for up to 4 years ]
    Language comprehension and expressive language
  • Vineland Adaptive Behavior Scales - Survey Edition [ Time Frame: yearly for up to 4 years ]
    Parent interview on child's adaptive functioning


Original Secondary Outcome:

Information By: University of California, Los Angeles

Dates:
Date Received: October 18, 1999
Date Started: May 1998
Date Completion:
Last Updated: May 26, 2015
Last Verified: May 2015