Clinical Trial: Evaluation of the Efficiency of Treatment by BUMETANIDE on Autistic Children With a Known Ethiology

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Evaluation of the Efficiency of Treatment by BUMETANIDE on Autistic Children With a Known Ethiology : Multicenter and Double Blind-study With Randomized Parallel Group, Ag

Brief Summary:

During a previous therapeutic trial, investigators showed that the bumetanide improved significantly autism. This trial showed that a therapeutic response was obtained in 75% of cases.

These first results were reinforced by a study led with adult patients for whom the eye tracking measurements as well as the functional MRI showed a diminution of the response time and a modification (amplification) of the cerebral response during an emotions recognition test.

Finally, investigators confirmed the physiological mechanism behind the action of the bumetanide in a study in two mouse models of autism.

Detailed Summary:
Sponsor: University Hospital, Limoges

Current Primary Outcome: Change (evolution) between day 0 and day 99 of the result of the scale CARS (Childhood Autism Rating Scale). [ Time Frame: Day 0 and Day 99 ]

Original Primary Outcome: Same as current

Current Secondary Outcome: CARS (Childhood Autism Rating Scale) between D0 and D99 and between D99 and D190 which will be describe by etiology [ Time Frame: Day 0, Day 99 and Day 190 ]

Original Secondary Outcome: Same as current

Information By: University Hospital, Limoges

Dates:
Date Received: October 25, 2016
Date Started: December 2016
Date Completion: June 2020
Last Updated: October 27, 2016
Last Verified: October 2016