Clinical Trial: Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation

Brief Summary: Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.

Detailed Summary: Chronic aortic regurgitation (AR) is a progressive process which causes both left ventricular volume and pressure overload. While the volume overload is associated with the degree of the aortic regurgitant volume, the pressure overload occurs as a result of systemic hypertension developed due to increased stroke volume. In early stages, excentric hypertrophy occurs aiming to compensate the volume overload in the left ventricle. Therefore , ejection fraction remains in normal range despite the increasing volume overload. Left ventricular dilatation and impairment in ejection fraction only occur in the end stages of the disease. Asymptomatic patients with chronic aortic regurgitation (AR) have a good prognosis in the presence of preserved systolic function. Therefore it is a challenge to identify patients with subclinical left ventricular (LV) dysfunction. Velocity vector imaging (VVI) is a new echocardiographic method based on two dimensional gray scale imaging, which is angle independent and can provide more accurate data about cardiac function.
Sponsor: Florence Nightingale Hospital, Istanbul

Current Primary Outcome: Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates [ Time Frame: April 2008 ]

Original Primary Outcome: · Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates · Tissue Doppler derived peak systolic velocity:Sa, peak systolic velocity during isovolumic contraction: IVV, isovolumic myocardial acceleration :IVA [ Time Frame: April 2008 ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Florence Nightingale Hospital, Istanbul

Dates:
Date Received: February 19, 2008
Date Started: March 2008
Date Completion:
Last Updated: June 27, 2008
Last Verified: June 2008