Clinical Trial: Aortic Dimensions in Turner Syndrome

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.

Brief Summary: An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Detailed Summary:
Sponsor: University of Aarhus

Current Primary Outcome: Aortic diameter at 3 well-defined levels measured by MRI and ECHO [ Time Frame: 2-yearly for 6 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: 24hour ambulatory blood pressure [ Time Frame: 24h 2-yearly for 6 years ]

Original Secondary Outcome: Same as current

Information By: University of Aarhus

Dates:
Date Received: February 19, 2008
Date Started: August 2003
Date Completion: June 2012
Last Updated: February 27, 2008
Last Verified: February 2008