Clinical Trial: Hypodontia and Ovarian Cancer
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational
Official Title: Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer.
Brief Summary:
The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones).
If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.
Detailed Summary:
Sponsor: University of Aarhus
Current Primary Outcome: Prevalence rates of hypodontia in women with ovarian cancer [ Time Frame: one year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Genetic causes for hypodontia and ovarian cancer [ Time Frame: two years ]
- Prevalence rates of hypodontia in patients with a known risk for epithelial cancer [ Time Frame: one year ]
Original Secondary Outcome: Same as current
Information By: University of Aarhus
Dates:
Date Received: November 9, 2011
Date Started: September 2011
Date Completion: August 2015
Last Updated: October 31, 2013
Last Verified: October 2013
