Clinical Trial: The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis

Brief Summary: The purpose of this study was to investigate the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.

Detailed Summary:

The diagnosis of anaphylaxis is based primarily on the clinical history. In some circumstances, inability to confirm the clinical diagnosis such as present with unusual manifestation, or when skin signs are absent likely contributes to underrecognition and undertreatment of the disease.

Currently, products of mast cell activation (histamine and total tryptase) can be measure in clinical laboratories as markers of acute anaphylaxis events, however these tests have clinically relevant limitations.

Therefore, development of laboratory tests with improved sensitivity and specificity that will support the clinical diagnosis of anaphylaxis are needed.

In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.

Sponsor: Mahidol University

Current Primary Outcome: Change of Serum tryptases [ Time Frame: baseline and 60 minutes after the onset of symptoms ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Mahidol University

Dates:
Date Received: June 12, 2012
Date Started: June 2006
Date Completion:
Last Updated: June 14, 2012
Last Verified: June 2012