Clinical Trial: Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Open-label, Single-center Study of Whether Oral Penicillin Desensitization of Healthy Sensitive Subjects Results in Allergen Cross-desensitization of Mast Cells by Skin Testing and Desensitization of
Brief Summary: This is an open-label, single-center study of whether oral penicillin desensitization of healthy sensitive subjects results in allergen cross-desensitization of mast cells by skin testing and desensitization of peripheral blood basophils. The primary endpoint(s) will be PC3 prick skin test values to penicillin, aeroallergen(s) and codeine. Secondary endpoints will be levels of Syk in purified basophils determined by flow cytometry (mean fluorescence intensity) and basophil degranulation (% tryptase release) to anti-FcåRI and to calcium ionophore.
Detailed Summary:
Sponsor: Virginia Commonwealth University
Current Primary Outcome: Decreased skin test sensitivity to Pre-pen (PC3 value) [ Time Frame: June 2012 ]
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Virginia Commonwealth University
Dates:
Date Received: March 23, 2009
Date Started: January 2009
Date Completion:
Last Updated: April 10, 2014
Last Verified: April 2014