Clinical Trial: Clonal Mast Cell Disorders in Exercise-Induced Anaphylaxis

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Detection of Clonal Mast Cell Disorders Among Patients With Exercise-induced Anaphylaxis

Brief Summary: Anaphylaxis is a serious allergic reaction that develops rapidly and can cause death. Some patients experience anaphylaxis is association with exercise, a disorder called exercise-induced anaphylaxis. A subset of patients with unexplained anaphylaxis, especially those with hypotension during the anaphylactic episodes, have been shown to have abnormal, clonal populations of a certain cell type, mast cells, in the bone marrow. This has been described in at least one patient with exercise-induced anaphylaxis. The investigators would like review the findings in a group of patients with exercise-induced anaphylaxis who have undergone evaluation for the presence of abnormal, clonal mast cells.

Detailed Summary:
Sponsor: Brigham and Women's Hospital

Current Primary Outcome:

  • Number of participants with presence of clonal abnormalities in the bone marrow specimen [ Time Frame: Baseline ]
    Presence of clonal mast cells in bone marrow as assessed by D816V c-kit mutation or CD25 will be recorded for each participant.
  • Number of participants with presence of clonal abnormalities in the bone marrow specimen [ Time Frame: Baseline ]
    Presence of clonal mast cells in bone marrow as assessed by D816V c-kit mutation or CD25 will be recorded for each participant. The data will be reported as the number of participant with exercise induced anaphylaxis carrying these clonal mast cells in this observational study. Presence of mast cells will be correlated with clinical parameters such as symptoms experienced during anapylaxis.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Brigham and Women's Hospital

Dates:
Date Received: March 29, 2011
Date Started: March 2011
Date Completion:
Last Updated: March 30, 2011
Last Verified: March 2011