Clinical Trial: Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis

Brief Summary: In this study, the investigators evaluated molecular biomarkers which play a role in the development of generalized aggressive periodontitis (GAgP) using gingival tissue samples through omics-based whole-genome transcriptomic while using healthy individuals as background controls.

Detailed Summary:

Aggressive periodontitis (AgP) is an inflammatory periodontal disease which is complex, multifactorial, and destructive. Progression and severity of the disease depend on interacting risk factors such as: immunological, microbiological, environmental, and genetic factors, as well as age, sex, and race.Some patients are genetically predisposed to AgP; they have immunological abnormalities, which are thought to be under genetic control. However, high susceptibility for periodontal destruction and the relationship between inflammatory changes, and genetic factors remain unclear.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of AgP and generate further information other than clinical signs and symptoms of AgP.

The aim of this study was to identify gene-expression patterns of patients with generalized aggressive periodontitis by whole-transcriptome gene-expression analyses.

Sponsor: Kocaeli University

Current Primary Outcome: mRNA quantification [ Time Frame: 2 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Definition of gen networking and new molecular pathways [ Time Frame: 2 months ]

Original Secondary Outcome: Same as current

Information By: Kocaeli University

Dates:
Date Received: December 17, 2014
Date Started: February 2013
Date Completion:
Last Updated: December 24, 2014
Last Verified: December 2014