Clinical Trial: Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
Brief Summary:
Acetazolamide, or Diamox, is the standard medical prophylaxis agent for high altitude illness. The medication is effective in preventing acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE). Its mechanism is via inhibition of the carbonic anhydrase enzyme which counteracts the respiratory alkalosis which occurs during ascent to altitude. It facilitates the excretion of bicarbonate in the urine. As a result, acetazolamide hastens acclimatization and helps prevent high altitude disorders.
Current recommended dosing is 125 mg, orally twice daily, started 24 hours prior to ascending in elevation. Side effects include tingling of the fingers and toes and perioral numbness which may be erroneously interpreted as stroke symptoms. Since acetazolamide is a mild diuretic, frequent micturition may occur leading to interruption of daytime activities as well as broken sleep. These effects can affect safety at high altitude. Acetazolamide is normally discontinued 2 days after the user has reached their highest elevation or a plateau in elevation.
A lower dose may be just as effective in preventing high altitude illnesses while preventing the disconcerting side effects resulting from its use. A smaller dose has not been studied, however. We will compare the common dose of 125 mg twice daily with a lower dose of 62.5 mg twice daily.
Detailed Summary:
Sponsor: University of Utah
Current Primary Outcome: Prevention of acute mountain sickness as measured by the Lake Louise Score [ Time Frame: 1 year ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Side effect profile of acetazolamide [ Time Frame: 1 year ]
Original Secondary Outcome: Same as current
Information By: University of Utah
Dates:
Date Received: November 12, 2013
Date Started: March 2012
Date Completion:
Last Updated: November 28, 2016
Last Verified: November 2016
