Clinical Trial: Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Propofol and Sevoflurane on Base Excess, pH and Lactate in Pediatric Heart Catheterisation

Brief Summary: Propofol is routinely used for general anesthesia during pediatric heart catheterisation. Propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined by bradycardia with progress to asystolia during propofol infusion. Metabolic acidosis is regarded as an early warning sign of PRIS. In this study the effect of propofol and sevoflurane on serum base excess, pH and lactate are examined during pediatric heart catheterisation.

Detailed Summary: In this prospective randomised study 40 children are anesthetised for pediatric heart catheterisation with propofol (N = 22) or sevoflurane (N = 18) with ethic committee approval. Base excess, pH and lactate were measured by blood gas analysis at the beginning, during and at the end of the procedure. Changes relative to baseline were analysed by paired t-Test with correction for multiple testing. The study was powered to detect a difference of 1.5 mmol/l for base excess and lactate.
Sponsor: University of Schleswig-Holstein

Current Primary Outcome: Serum Lactate [ Time Frame: 4 hours ]

Serum lactate is measured during application of propofol and sevoflurane to examine the effect on metabolic acidosis.


Original Primary Outcome: Same as current

Current Secondary Outcome: pH and base excess [ Time Frame: Hours ]

pH and base excess are measured during application of Propofol and Sevoflurane to examine the effect on acid-base balance


Original Secondary Outcome: Same as current

Information By: University of Schleswig-Holstein

Dates:
Date Received: February 9, 2011
Date Started: June 2009
Date Completion:
Last Updated: March 10, 2011
Last Verified: February 2011